Can AI Be Your Nutritionist? GLP-1s and Weight Health with Ashley Koff
October 22, 2026 · 1 hr 21 min
Why listen
A registered dietitian explains what GLP-1 prescribers rarely tell you about weight, hunger, and nutrition.
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In this episode
- Why zero appetite on a GLP-1 can signal the dose is off, not working
- What you actually lose when the scale drops: muscle, bone, hair, hormones
- How to eat in the first two days after a weekly injection
- Why calories are only potential energy until your digestion does its job
About this episode
Every bad thing you’ve heard about GLP-1s may be true, and so is everything you’ve been told about calories in, calories out. Ashley Koff says both miss the real problem.
Jeff sits down with Ashley Koff, RD, a registered dietitian and author of Your Best Shot, to talk about GLP-1s, weight health, and whether AI can ever be as curious as a good practitioner. Jeff shares what happened when he started low-dose tirzepatide and his appetite disappeared overnight.
- Why "weight loss" can include bone, muscle, hair and testosterone, and what Ashley measures instead
- The first two days after a weekly shot: why she moves fiber later in the week and leans on soups and smoothies
- Why feeling no hunger at all on a GLP-1 can be a sign the dose is wrong
- Why calories are "only potential energy" until digestion turns them into something usable
- How Jeff used AI to keep five specialists on the same page for his father, and why Ashley built her own AI nutritionist
This episode is for anyone who started a GLP-1 and can barely eat, or who's getting textbook nutrition answers that don't fit their body. Ashley's book Your Best Shot is available now.
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