Commune with Jeff Krasno
GLP-1s Gave Me the Ick: A Personal Metabolic Experiment
· 18 min
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About this episode
Ten pounds in two weeks. No hunger. No craving for coffee or alcohol. This is Jeff’s personal, week-by-week account of starting tirzepatide (sold as Zepbound), tracked through blood sugar, cholesterol markers, and a noticeable dimming of everyday motivation and joy.
- What changed in the first two weeks: appetite, weight, and energy
- Tracking glucose, LDL, ApoB, and other metabolic markers with a CGM and blood panels
- Why alcohol and coffee stopped feeling rewarding
- The emerging link between GLP-1s, dopamine, and the brain's reward circuitry
- The trade-off between appetite control and a sense of vitality or spark
This episode is for anyone weighing GLP-1s for themselves, or curious what the drugs are actually like beyond the headlines.
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About Commune with Jeff Krasno
The Commune Podcast is where we explore the ideas and practices that help us live healthy, connected, purpose-filled lives.
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