Commune with Jeff Krasno
GLP-1s Gave Me the Ick: A Personal Metabolic Experiment
July 25, 2026 · 18 min
Why listen
A week-by-week account of what tirzepatide actually does to your body, mood, and motivation.
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In this episode
- What changed in appetite, weight, and energy in the first two weeks
- How blood sugar, LDL, and ApoB shifted with CGM and blood panel tracking
- Why alcohol and coffee stopped feeling rewarding on the drug
- The real trade-off between appetite control and losing your sense of spark
About this episode
Ten pounds in two weeks. No hunger. No craving for coffee or alcohol. This is Jeff’s personal, week-by-week account of starting tirzepatide (sold as Zepbound), tracked through blood sugar, cholesterol markers, and a noticeable dimming of everyday motivation and joy.
- What changed in the first two weeks: appetite, weight, and energy
- Tracking glucose, LDL, ApoB, and other metabolic markers with a CGM and blood panels
- Why alcohol and coffee stopped feeling rewarding
- The emerging link between GLP-1s, dopamine, and the brain's reward circuitry
- The trade-off between appetite control and a sense of vitality or spark
This episode is for anyone weighing GLP-1s for themselves, or curious what the drugs are actually like beyond the headlines.
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About Commune with Jeff Krasno
The Commune Podcast is where we explore the ideas and practices that help us live healthy, connected, purpose-filled lives.
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